Projects
Different strategies will be employed to discover tools and drugs for novel types of drug targets. The research program focuses on 9 research projects from four core themes that are closely interconnected:
- targeted protein degraders
- macrocyclic natural product-derived drugs
- biopolymers as tools and drugs, and
- drug conjugates
Project overview
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P1: Exploring the chemical space of cereblon ligands: an access to new PROTACs
(Gütschow/Steinebach) Research Area: Medicinal Chemistry, Drug Synthesis
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P2: Solid-phase synthesis of selective histone deacetylase degraders
(Hansen) Research Area: Pharmaceutical & Medicinal Chemistry
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P3: Design and synthesis of simplified polyketide antibiotics as improved antibacterial agents
(Menche/A. Müller) Research Area: Natural product synthesis and biological evaluation for antimicrobial activity
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P4: Biosynthetic and structure-activity investigations on translation-inhibiting cyclic peptide natural products
(Crüsemann) Research Area: Pharmaceutical Biology
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P5: Sulfated natural polyglycosides and their non-glycosidic synthetic mimetics as multitarget ligands in (immuno)oncology
(Bendas) Research Area: Pharmaceutical Chemistry & Cell Biology
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P6: Antimicrobial and immunodulatory activities of (hidden) host defense peptides
(Schneider, Weindl) Research Area: Pharmacology & Microbiology
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P7: Designing engineered proteins to foster development of unnatural natural ligands: A chemogenetic proof-of-concept study
(Kostenis) Research Area: Pharmacology & Cell Biology
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P8: Targeted induction of T-cell activation through optimized aptamer-antigen conjugates
(Mayer) Research Area: Chemical Biology & Medicinal Chemistry
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P9: Molecular conjugates of ligands for the orphan G protein-coupled receptor GPR84
(C.E. Müller) Research Area: Medicinal Chemistry, Structural Biology & Molecular Pharmacology